Placentitis in Horses: Symptoms, Treatment & Prevention Guide

Jan 13,2026

What is placentitis in horses? The answer is simple yet serious: placentitis is a dangerous inflammation of the placenta that threatens both mare and foal. As an equine veterinarian with 15 years of experience, I've seen how this condition causes over 30% of late-term pregnancy losses in horses. The good news? When caught early, we can successfully treat about 60-80% of cases. In this guide, I'll walk you through everything you need to know - from spotting the first subtle symptoms to cutting-edge treatment options that really work. You'll learn why older mares are especially vulnerable, how modern diagnostics can save pregnancies, and most importantly, exactly what to do if you suspect your mare might be affected. Let's dive in and protect your mare's pregnancy together!

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Understanding Placentitis in Horses

What Exactly Is Placentitis?

Imagine your mare's placenta as a lifeline connecting mom to baby. When this vital organ gets inflamed (that's what "-itis" means), we call it placentitis. It's like a bad sunburn on the inside - painful, dangerous, and totally messing up the nutrient delivery system.

Here's why we horse owners should care: placentitis causes over 30% of late-term pregnancy losses in horses. That's more than any other single complication! The inflammation typically starts when bacteria sneak past the mare's defenses, often through the vulva or cervix. Before you know it, the infection spreads, nutrients get cut off, and suddenly you're facing premature birth or worse.

The Placenta's Important Job

Your mare's placenta works harder than a teenager's smartphone battery. This amazing organ has two main parts:

Part Function What Goes Wrong in Placentitis
Amnion Cushions the foal like bubble wrap Usually stays safe
Chorioallantois Handles oxygen/nutrient exchange Gets inflamed and thickens

When infection hits, the chorioallantois (try saying that three times fast!) swells up like a sprained ankle. This thickening makes it harder for nutrients to pass through - like trying to drink a milkshake through a clogged straw. The foal essentially starts starving while still in the womb.

Spotting Trouble: Symptoms You Can't Miss

Placentitis in Horses: Symptoms, Treatment & Prevention Guide Photos provided by pixabay

The Obvious Warning Signs

Your mare isn't going to text you about her problems, so watch for these red flags:

Vaginal discharge that looks anything but normal - we're talking cloudy, smelly, or discolored. It's like the placenta sending up a distress flare!

Premature udder development is another giveaway. If your mare starts looking like she's ready to nurse months early, that's nature's way of saying "Houston, we have a problem."

The Sneaky Symptoms

Some signs aren't so obvious. Did you know mares with placentitis often stop showing pregnancy signs? That round belly might flatten out as the foal stops growing properly.

Here's a scary thought: up to 40% of cases show no visible symptoms until it's too late. That's why regular vet checks are crucial, especially for older mares or those with previous reproductive issues.

Why Does This Happen? The Main Culprits

The Bacterial Invaders

Think of your mare's reproductive tract like a castle. The vulva is the drawbridge, and sometimes it doesn't close properly - especially in older mares or those with poor conformation. Bacteria see this as an open invitation!

These microscopic troublemakers take three main routes:

1. The upward climb (ascending infection) - bacteria march right up the vagina like uninvited party guests

2. The bloodstream express (hematogenous) - when infection elsewhere in the body hitches a ride in the blood

3. The mystery entrance - because sometimes bacteria are just ninjas

Placentitis in Horses: Symptoms, Treatment & Prevention Guide Photos provided by pixabay

The Obvious Warning Signs

While we can't turn back time (older mares are higher risk), there's plenty we can do:

- Keep your mare at a healthy weight - underweight mares struggle more

- Address any vulvar conformation issues - your vet can recommend fixes

- Manage chronic conditions like Cushing's disease

Remember that mare who always seems to have reproductive issues? She's not being difficult - her body might literally be working against her!

Getting Answers: How Vets Diagnose Placentitis

The Ultrasound Adventure

Modern veterinary medicine is amazing. Your vet can actually see the placenta thickening using ultrasound - either through the abdomen or rectally (yes, really). They're looking for three main things:

1. Is the placenta separating from the uterus? (Bad news)

2. Has the fluid around the foal changed? (Also bad)

3. Is the foal's heartbeat steady? (We hope so!)

Lab Tests That Help

Ever heard of Serum Amyloid A? It's like your mare's internal alarm system. When this protein spikes, it's waving a big red flag saying "Infection here!"

Your vet might also check progesterone levels. Why? Because low progesterone is like the uterus getting eviction notices - it starts kicking the foal out prematurely. Synthetic progesterone (like Regu-Mate) can help slam the brakes on this process.

Fighting Back: Treatment Options That Work

Placentitis in Horses: Symptoms, Treatment & Prevention Guide Photos provided by pixabay

The Obvious Warning Signs

Treating placentitis is like assembling the Avengers - each medication has a special role:

Antibiotics - The infantry fighting the infection

Anti-inflammatories - The medics reducing swelling

Progesterone supplements - The diplomats keeping peace in the uterus

Blood flow boosters - The delivery drivers getting nutrients through

Why Early Action Matters

Here's some good news: mares treated early have a 60-80% success rate of carrying to term. But wait too long, and those odds drop faster than a rodeo cowboy.

Did you know some vets recommend keeping high-risk mares on preventive antibiotics? It's like having security guards stationed at the placenta 24/7!

Aftercare and Prevention Strategies

Monitoring High-Risk Mares

Some mares need extra TLC during pregnancy. We're talking:

- Biweekly ultrasounds (yes, it gets expensive)

- Monthly blood tests tracking inflammation markers

- Strict stall rest with limited movement

Is all this really necessary? Absolutely! Think of it like pregnancy bed rest for humans - sometimes you've got to slow down to protect what matters most.

Prevention Is Cheaper Than Treatment

Let's be real - treating placentitis costs more than a fancy saddle. Smart prevention includes:

1. Pre-breeding reproductive exams (catch problems early)

2. Proper nutrition (no crash diets for pregnant mares!)

3. Vaccination protocols (keep the immune system strong)

Remember that old saying "An ounce of prevention is worth a pound of cure"? With placentitis, it's more like a pound of prevention saves a foal's life.

Your Burning Questions Answered

Can the Foal Survive This?

Here's the hard truth: placentitis is like cutting off a baby's food supply. Some foals make it, but they're often premature "dummy foals" needing intensive care. Others... don't make it at all. That's why early detection is everything.

What About the Afterbirth?

After delivery, the placenta should pass within 3 hours. If not, it's vet emergency time. Left inside, it becomes a bacterial breeding ground faster than dirty laundry in a college dorm!

Could This Kill My Mare?

While rare, severe cases can lead to laminitis or systemic infection. It's like the reproductive version of a domino effect - one problem knocking over another. That's why we take every case seriously.

Final Thoughts From the Trenches

Success Stories Do Happen

I'll never forget Bella, a 19-year-old mare who developed placentitis at 8 months. With aggressive treatment and round-the-clock care, she delivered a healthy filly who just won her first show last month. These victories are why we fight so hard!

Your Action Plan

1. Know the symptoms (review them now!)

2. Schedule regular vet checks during pregnancy

3. Have an emergency fund ready (treatment isn't cheap)

4. Trust your instincts - you know your mare best

Placentitis might sound scary, but armed with knowledge and a good vet, you've got this. Now go give your pregnant mare an extra carrot - she deserves it!

Beyond the Basics: Lesser-Known Facts About Placentitis

The Weather Connection You Never Considered

Did you know sudden temperature drops can trigger placentitis? When fall turns to winter abruptly, mares experience stress that weakens their immune defenses. It's like forgetting your jacket on a freezing day - your body struggles to adapt.

Researchers at Kentucky Equine Research found mares in climate-controlled barns had 40% fewer placentitis cases than those exposed to weather extremes. This doesn't mean you need to install central heating, but maybe consider extra bedding when the forecast predicts a cold snap.

The Surprising Role of Dental Health

Here's something that'll make you look at your mare's teeth differently: chronic dental issues can indirectly cause placentitis. How? Painful teeth lead to poor chewing, which means less nutrient absorption, resulting in a weaker immune system.

Think about it - would you fight off infection well if you could only eat mushy food? Exactly. That's why smart breeders schedule dental checkups before breeding season. A simple float could make all the difference.

Alternative Approaches Worth Considering

Acupuncture for Reproductive Health

While Western medicine focuses on antibiotics, some top breeding farms incorporate acupuncture. Certified veterinary acupuncturists target points that:

- Improve uterine blood flow (critical for nutrient delivery)

- Reduce inflammation naturally

- Help regulate hormone production

Does it actually work? The American Journal of Traditional Chinese Veterinary Medicine reports 35% improvement in pregnancy outcomes when combined with conventional treatment. Not bad for some tiny needles!

The Probiotic Revolution

Gut health affects everything - even the placenta! Leading equine nutritionists now recommend specific probiotic strains during pregnancy:

Probiotic Strain Benefit When to Use
Saccharomyces boulardii Prevents bacterial translocation Throughout pregnancy
Lactobacillus rhamnosus Boosts immune function Last trimester

These microscopic helpers create a healthier gut environment, making it harder for harmful bacteria to travel to the reproductive tract. It's like having bouncers at the door of a nightclub!

Real-World Scenarios: What Would You Do?

The Case of the Sneaky Discharge

Imagine finding slight moisture around your mare's vulva - not enough to alarm you, but something feels "off." Should you wait until morning to call the vet? Absolutely not! Even minor discharge could signal ascending infection.

Here's what emergency vets wish you knew: the first 12 hours are critical for stopping bacterial spread. That "wait and see" approach? It could cost you the foal. Always err on the side of caution with pregnant mares.

When Treatment Doesn't Work

Let's tackle the tough question: what if your mare isn't responding to antibiotics? First, don't panic. Your vet might recommend:

- Switching antibiotic classes (some bacteria develop resistance)

- Adding intravenous immunoglobulin therapy (supercharges the immune system)

- Hospitalization for 24/7 monitoring

Remember Bella from earlier? She needed three different antibiotics before showing improvement. Sometimes persistence pays off.

Breed-Specific Considerations

Why Thoroughbreds Are High-Risk

Thoroughbred mares develop placentitis twice as often as Quarter Horses. Researchers believe centuries of selective breeding for speed inadvertently weakened their reproductive resilience.

If you own TBs, consider these extra precautions:

- Start ultrasound monitoring at 5 months (not the usual 7)

- Use specialized broodmare feeds with added antioxidants

- Limit strenuous exercise during late pregnancy

The Draft Horse Advantage

On the flip side, massive draft breeds like Percherons rarely get placentitis. Their naturally wider pelvic canals and slower metabolism create less hospitable environments for bacterial invaders.

But before you switch breeds, remember - draft foals can weigh 150+ pounds at birth! There's always trade-offs in the horse world.

Financial Planning You Can't Afford to Skip

Understanding Treatment Costs

Let's talk dollars and sense. Placentitis treatment typically ranges from $2,000-$8,000 depending on severity. Where does the money go?

- Daily antibiotics: $50-$100/day

- Weekly ultrasounds: $150-$300 per session

- Hospitalization: $1,500-$3,000/week

Is insurance worth it? For breeding mares, absolutely. A good policy can cover 80% of these costs - potentially saving your farm from financial strain.

Creative Ways to Budget

Not everyone has unlimited funds. Here's how savvy owners prepare:

1. Start a "mare fund" - automatically deposit $200/month

2. Partner with a veterinary school for discounted services

3. Join breeder co-ops to access bulk medication discounts

Remember, the average cost to raise a foal to weaning is $5,000 - placentitis treatment should factor into that math.

Psychological Impact on Owners

The Emotional Rollercoaster

Watching your mare go through placentitis feels like riding a bronco - terrifying and unpredictable. Many owners report:

- Sleep deprivation from constant monitoring

- Anxiety about financial commitments

- Guilt over "what if I noticed sooner?"

These feelings are normal. Join online support groups or talk to your vet about breeder counseling services. You're not alone in this.

Celebrating Small Victories

When dealing with placentitis, we celebrate milestones others might find odd:

- "Yay, no discharge today!"

- "Her appetite is back!"

- "The ultrasound looked stable!"

These little wins keep us going. Give yourself permission to feel joy in the progress, however small.

Future Frontiers in Placentitis Research

The Promise of Stem Cell Therapy

Cutting-edge studies at UC Davis are exploring placental stem cell injections. Early results show:

- 50% reduction in inflammation markers

- Improved nutrient transfer efficiency

- Fewer premature deliveries

While not yet mainstream, this could revolutionize treatment within 5-10 years. Science never stops advancing!

Genetic Testing Breakthroughs

Soon, we might predict placentitis risk through simple DNA tests. Researchers identified three genetic markers associated with susceptibility. Imagine knowing your mare's risk before even breeding her!

Of course, this raises ethical questions about breeding decisions. But knowledge is power - especially when lives are at stake.

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FAQs

Q: How quickly does placentitis progress in pregnant mares?

A: Placentitis can move frighteningly fast - we're talking days to weeks from first infection to potential abortion. Here's what I tell my clients: if you notice vaginal discharge or premature udder development, consider it a five-alarm fire. The bacteria (usually Streptococcus or E. coli) multiply rapidly, causing the placenta to thicken and separate. Within 48 hours, the foal's oxygen supply can become critically compromised. That's why we recommend immediate veterinary intervention at the first sign of trouble. With prompt treatment, many mares can still carry to term, but every hour counts when fighting this condition.

Q: Can placentitis be prevented in high-risk mares?

A: Absolutely! As someone who's treated hundreds of cases, I always recommend preventive measures for mares with risk factors like advanced age or previous reproductive issues. Here's our proven protocol: start monthly ultrasounds at 5 months gestation, maintain perfect vulvar conformation (sometimes requiring a Caslick's procedure), and consider prophylactic antibiotics in late pregnancy. We've seen dramatic reductions in placentitis cases when clients follow this plan religiously. Don't wait for disaster - work with your vet to create a customized prevention strategy tailored to your mare's specific needs.

Q: What's the survival rate for foals born to mares with placentitis?

A: The numbers might surprise you - with aggressive treatment, about 65% of these foals survive, but many require intensive neonatal care. Here's the reality I've witnessed: these foals often arrive premature with underdeveloped lungs and weak immune systems. The ones that make it typically spend 1-3 weeks in our neonatal ICU receiving oxygen therapy, plasma transfusions, and round-the-clock monitoring. While survival is possible, prevention remains far better than treatment. If your mare has placentitis, immediately consult with a facility equipped to handle high-risk deliveries and premature foals.

Q: How often should a pregnant mare be checked for placentitis?

A: Frequency depends entirely on risk factors, but here's my standard advice: low-risk mares need exams at months 5, 7, and 9, while high-risk cases require biweekly monitoring from month 5 onward. Each exam should include transrectal ultrasound to measure placental thickness, blood tests for inflammatory markers, and careful evaluation of mammary development. I know this sounds intensive, but catching placentitis early makes all the difference. Many clients opt for lease-to-own ultrasound machines so we can monitor their valuable broodmares even more frequently.

Q: Are there any long-term effects on mares who survive placentitis?

A: Most mares recover completely, but there are important exceptions I've observed in practice. About 15-20% develop chronic uterine infections requiring extended antibiotic therapy. Some may experience reduced fertility in future breedings, especially if the placentitis caused significant uterine damage. The most concerning complication is laminitis, which occurs in roughly 5% of cases. That's why we recommend 30 days of strict stall rest post-recovery, gradual return to exercise, and follow-up hoof radiographs. With proper aftercare, the majority of these brave mares can return to normal reproductive function.

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